By Gilbert N Ling
Unique 1963 evaluate by way of Jay Jacobs, MD:
A actual conception of the residing nation: The Association-Induction speculation. through GILBERT Ning LING, B.Sc., PH.D., Director of the dept of Molecular Biology, Pennsylvania Hospital.
Cloth, Pp. 680, with illustrations. Blaisdell Publishing Co.,A department of Random residence. Inc., long island, London, 1962.
The writer has been famous in his box for 15 years. His paintings is praised by means of his friends, together with Dr. C. N. Yang, a Nobel Laureate in Physics. This publication was once written to coordinate actual chemistry, biochemistry and body structure, and clarify the various intricacies of residing tissue.
The contents are on such a sophisticated point that these acquainted with one element should be baflled via others. to assist in overcoming this hassle and to bridge the space among clinical disciplines there's a word list of seventy one pages.
Unfortunately, the mathematical calculations in a few parts are too advanced for somebody who has now not had really expert training.
The diversity of topics is wide; habit of Ions, nonelectrolytes and proteins; mobile potentials and permeabillty; excitatton, contraction and inhibition; the activities or enzymes, hormones, and medication; progress and neoplasm. The author's "association-induction" speculation is drawn upon to provide an explanation for the phenomena or chemical motion in residing tissue. This speculation states that the associatlon among proteins and interacting debris is severely diverse in vivo and In vitro, and that the first functionality of the polarizable resonating chain of a protein is to supply a automobile for the transmission of an inductive effect.
The publication comprises many tables, graphs, diagrams and mathematical calculations to aid its theses. The bibliography and references are extensive.
Every health care provider may still learn a few parts of this publication, to determine how a ways the fundamental scientists have are available in realizing the habit of dwelling tissue. it's of worth largely as a reference publication to these whose paintings is on the simple technological know-how point.
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Extra resources for A Physical Theory of the Living State the association-induction hypothesis
Proteins, Amino Acids and Peptides as Ions and Dipolar Ions," pp. 468-477. Reinhold, New York, 1943. A brief review and critique of the Linderstr¢m-Lang theory of proteins in solution. *A more correct name for a fixed-charge system would be "fixed-polar-group system" because, strictly speaking, the charge-hearing groups are fixed, not the charge itself. " t Received dates are those on which chapters arrived at Blaisdell Publishing Company. , Deuterium isotope effects in chemistry and bioiogy.
29 kcal/mole remains, even though the two acid groups are separated by 14 carbon atoms. We may conclude that the fixation of two charged groups together makes dissociation from the second group more difficult than it would be if the groups were not fixed. In other words, an increase in the average association follows this most simple type of ionic-site fixation. The effect in question occurs also when many charged groups are fixed together either by covalent bonds or through micellar aggregation resulting from the action of short-range van der Waals' forces.
Lewis (1934) and of Barbour and Dickerson (1939) shows that D 20 has profound influence on living processes in vivo as well as in vitro. , 1960; J. J. ) (3) In the Linderstrjlim-Lang theory, a protein molecule is characterized by both its molecular weight, which determines the radius of the hypothetically spherical molecule, and its net charge. These are not sufficient to describe the INTRODUCTION xxix physiological activity of a protein: (a) Biological function cannot be specified solely on the basis of the protein molecular weight.