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By Achille Cappiello

The several LC-MS thoughts to be had this present day have been constructed to fit particular analytical wishes and the appliance diversity lined through every one is huge, yet nonetheless restricted. GC amenable compounds may be all analyzed with a unmarried GC-MS process while HPLC functions demand particular LC-MS instrumental preparations. ESI, APCI, APPI, and EI are ionization concepts that may be mixed with diversified analyzers, in unmarried or tandem configuration, to create the last word procedure for a definite software. as soon as forthcoming LC-MS for a selected want, the short technical evolution and the variegated advertisement provide can result in confusion within the power user.The function of this publication is to enlighten the cutting-edge of LC-MS evolution via a sequence of contributions written by means of the folks that introduced significant, contemporary ideas within the box. each one bankruptcy will think about the novelties, the benefits and the prospective purposes lined through a specific technical answer. The publication also will comprise new analytical equipment which may offer merits utilizing the latest ideas in LC-MS plus a definite variety of key applications.- includes contributions from significant innovators within the box- Covers the most recent advancements within the box of LC-MS- provides a transparent define at the merits of assorted suggestions and their purposes

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Salvadori and T. Netscher, Eur. J. Org. , (2003) 2840–2844. F. Mazzini, A. Mandoli, P. Salvadori, T. Netscher and T. Rosenau, Eur. J. Org. , (2004) 4864–4869. F. Mazzini, T. Netscher and P. Salvadori, Tetrahedron, 61 (2005) 813–817. qxd 11/11/2006 12:47 PM Page 27 Achille Cappiello (Editor) Advances in LC–MS Instrumentation Journal of Chromatography Library, Vol. V. 1 INTRODUCTION High-performance liquid chromatography (HPLC) and electron ionization mass spectrometry (EIMS) are two analytical techniques that, in principle, seem to be incompatible.

Howard, Y. L. Lafleur, Rapid Commun. , 6 (1992) 214–220. F. K. Boyd, S. A. B. L. Lafleur and Y. Makarovsky, Can. J. , 70 (1992) 2558–2568. F. Anacleto, L. M. K. A. Quilliam, Anal. , 67 (1995) 4145–4154. F. A. Quilliam, Anal. , 65 (1993) 2236–2242. C. Perazzolli, I. Mancini and G. Guella, Rapid. Commun. , 19 (2005) 461–469. A. Raffaelli, S. Pucci, R. Lazzaroni and P. Salvadori, Rapid Commun. , 11 (1997) 259–264. W. , Industrial Water Pollution Control, McGraw Hill, New York, NY, 1966, Chapter 6.

F. Anacleto, H. K. Boyd, S. A. G. B. Howard, Y. L. Lafleur, Rapid Commun. , 6 (1992) 214–220. F. K. Boyd, S. A. B. L. Lafleur and Y. Makarovsky, Can. J. , 70 (1992) 2558–2568. F. Anacleto, L. M. K. A. Quilliam, Anal. , 67 (1995) 4145–4154. F. A. Quilliam, Anal. , 65 (1993) 2236–2242. C. Perazzolli, I. Mancini and G. Guella, Rapid. Commun. , 19 (2005) 461–469. A. Raffaelli, S. Pucci, R. Lazzaroni and P. Salvadori, Rapid Commun. , 11 (1997) 259–264. W. , Industrial Water Pollution Control, McGraw Hill, New York, NY, 1966, Chapter 6.

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